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Rabbit IFN gamma Polyclonal Antibody - Biotinylated

KPB1309U-050
$300.00
Data SheetAdd to Cart
Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-gamma belongs. IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-gamma is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.

Reactivity - ELISA
Bovine IFN gamma - None
Canine IFN gamma - None
Caprine IFN gamma - None
Chicken IFN gamma - None
Dolphin IFN gamma - Weak
Equine IFN gamma - None
Feline IFN gamma - None
Ferret IFN gamma - None
Human IFN gamma - Weak
Mouse IFN gamma - None
Ovine IFN gamma - None
Rabbit IFN gamma - Strong
Swine IFN gamma - None
Zebrafish IFN gamma 1-1 - None
Zebrafish IFN gamma 1-2 - None

Rabbit IFN gamma ELISA Data
Rabbit IFN gamma Standard Curve

Catalog No.:
KPB1309U-050
Quantity:
50 ug
Country of Origin:
USA
Host:
The rabbit IFN gamma polyclonal antibody was produced in chickens.
Purification:
Antigen-affinity Purification
Immunogen:
Recombinant Rabbit IFN gamma
Applications:
The rabbit IFN gamma polyclonal antibody has been qualified for use in ELISA and Western blot applications.

28222511

Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.

Lambracht-Washington D, Fu M, Wight-Carter M, Riegel M, Rosenberg RN.

J Alzheimers Dis. 2017;57(1):97-112. doi: 10.3233/JAD-160947.

Applications: Determine frequencies of cytokine secreting cells by ELISPOT for rabbit IFN gamma, IL-17A, and IL-4.

Abstract
A pathological hallmark of Alzheimer's disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology. Active DNA Aβ42 immunizations administered with the gene gun into the skin elicits a different immune response and is non-inflammatory. While in rodents, good responses had been found for this type of immunization, positive results in larger mammals are missing. We present here results from sixteen New Zealand White Rabbits, which underwent intradermal DNA Aβ42 immunization via gene gun. The humoral immune response was analyzed from blood throughout the study, and cellular immune responses were determined from spleens at the end of the study. A good anti-Aβ antibody response was found in the rabbit model. The T cell response after re-stimulation in cell culture showed no IFNγ producing cells when ELISPOT assays were analyzed from PBMC, but low numbers of IFNγ and IL-17 producing cells were found in ELISPOTS from spleens (both 5 immunizations). Brains from immunized rabbits showed no signs of encephalitis. Based on these results, DNA Aβ42 immunization is highly likely to be safe and effective to test in a possible clinical AD prevention trial in patients.


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