Mouse Oncostatin M (OSM) Polyclonal Antibody - Biotinylated

Data SheetAdd to Cart
OSM (Oncostatin M) is a secreted cytokine involved in homeostasis and most chronic illnesses. OSM, a member of the IL-6 (gp130) family of proteins, inhibits the proliferation of a number of tumor cell lines and plays a significant role in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. Of all IL-6-type cytokines studied so far, OSM displays the broadest signaling profile. LIF and OSM proteins activate the JAK/STAT pathway, the MAPK protein kinases ERK1 and ERK2, the stress-activated protein kinases p38 and c-Jun N-terminal kinase (JNK), the phosphatidylinositol-3-kinase (PI3K) AKT pathway and protein kinase C delta (PRKCD). In addition, OSM exhibits many other effects by regulating the production of other cytokines including IL-6, G-CSF and GM-CSF in endothelial cells. OSM may be a tumor promoter that will provide a potential target for antiangiogenic therapy.

Reactivity - ELISA
Bovine OSM - None
Canine OSM - None
Human OSM - None
Mouse OSM - Strong
Swine CCL11 - None

Mousee OSM ELISA Data
Mouse OSM Standard Curve

Catalog No.:
50 ug
Country of Origin:
The Mouse OSM polyclonal antibody was produced in rabbits.
Antigen-affinity Purification
Recombinant Mouse OSM
The Mouse Oncostatin M polyclonal antibody has been qualified for use in Western Blot and ELISA applications.
None at this time

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