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Bovine IL-15 (Yeast-derived Recombinant Protein) - 5 micrograms

RP0009B-005
$150.00
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Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2 that is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. IL-15 was discovered to be a member of a family of cytokines, which also includes IL-2, IL-4, IL-7, IL-9, and IL-21. The specific receptor for IL-15, IL-15 receptor alpha, appears to regulate IL-15 secretion, stability, and activity. All members of this family use the common gamma chain as part of their signaling complex. IL-15 has been shown to play a role in many diseases, including obesity, influenza, and inflammatory autoimmune diseases.

Alternate Names - IL15, IL-15, interleukin 15

IL-15 Homology Across Species
Bos taurus (cattle) IL-15 – 100%
Bos mutus (wild yak) IL-15 – 100%
Bubalus bubalis (water buffalo) IL-15 – 100%
Bison bison (bison) IL-15 – 99%
Pantholops hodgsonii (chiru) IL-15 – 95%
​More - https://blast.ncbi.nlm.nih.gov/

Bovine IL-15 (Yeast-derived Recombinant Protein) - 5 micrograms
Catalog No.:
RP0009B-005
Quantity:
5 ug
Source:
The Bovine IL-15 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Bovine IL-15 recombinant protein has a predicted molecular weight of 13.2 kDa.
Protein Sequence:
NWQYVINDLK TIEHLIQSIH MDATLYTESD AHPNCKVTAM QCFLLELRVI LHESKNATIY EIIENLTMLA NSNLSSIENK TELGCKECEE LEEKSIKEFL KSFVHIVQMF INTS (114)
Country of Origin:
USA
Applications:
The Bovine IL-15 endotoxin-free recombinant protein can be used in cell culture, as an IL-15 ELISA Standard, and as a Western Blot Control.

30619358

Bovine Neonatal Monocytes Display Phenotypic Differences Compared With Adults After Challenge With the Infectious Abortifacient Agent Neospora caninum.

Sharma P, Hartley CS, Haque M, Coffey TJ, Egan SA, Flynn RJ.

Front Immunol. 2018 Dec 19;9:3011. doi: 10.3389/fimmu.2018.03011. eCollection 2018.

Applications: Stimulation of Bovine NK cells with bovine IL-15 in culture.

Abstract

The neonatal period represents a window of susceptibility for ruminants given the abundance of infectious challenges in their environment. Maternal transfer of immunity does not occur in utero but post-parturition, however this does not compensate for potential deficits in the cellular compartment. Here we present a cellular and transcriptomic study to investigate if there is an age-related difference in the monocyte response in cattle during intra-cellular protozoan infection. We utilized Neospora caninum, an obligate intracellular protozoan parasite that causes abortion and negative economic impacts in cattle worldwide, to study these responses. We found neonatal animals had a significant greater percentage of CD14+ monocytes with higher CD80 cell surface expression. Adult monocytes harbored more parasites compared to neonatal monocytes; additionally greater secretion of IL-1β was observed in neonates. Microarray analysis revealed neonates have 535 genes significantly upregulated compared to adult with 23 upregulated genes. Biological pathways involved in immune response were evaluated and both age groups showed changes in the upregulation of tyrosine phosphorylation of STAT protein and JAK-STAT cascade pathways. However, the extent to which these pathways were upregulated in neonates was much greater. Our findings suggest that neonates are more resistant to cellular invasion with protozoan parasites and that the magnitude of the responses is related to significant changes in the JAK-STAT network.


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