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Bovine IL-23, alpha subunit p19 Recombinant Protein (IL-23A) - 25 micrograms

RP0021B-025
$250.00
Data SheetAdd to Cart
Bulk pricing on proteins is available. Call us at 651-646-0089 or send us an email.

Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-beta 1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.

IL-23 p19 Homology Across Species
Bos indicus (zebu) IL-23 p19 – 99%
Bos mutus (wild yak) IL-23 p19 – 99%
Bubalus bubalis (water buffalo) IL-23 p19 – 98%
Pantholops hodgsonii (chiru) IL-23 p19 – 96%
Ovis aries (sheep) IL-23 p19 – 96%
Capra hircus (goat) IL-23 p19 – 95%
Bovine IL-23, alpha subunit p19 Recombinant Protein (IL-23A) - 25 micrograms
Catalog No.:
RP0021B-025
Quantity:
25 ug
Source:
The Bovine IL-23A recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Bovine IL-23A recombinant protein has a predicted molecular weight of 19.0 kDa.
Protein Sequence:
RAVSEDSSPA WTRGQQLSQQ LCMLAWSAHL PMGHMDLPRE EGGDKTTDDV PRIQCEDGCD PQGLRDNSQS CLQRIHRGLV FYEKLLGSDI FTGEPSLLPN GPVDQLHASI LGLRELLQPK GHHWETEQTP SPIPSQPWQR LLLRLKILRS LQAFVAVAAR VFAHGAATLS P (171)
Alias:
IL-23A
Country of Origin:
USA
Applications:
The Bovine IL-23 endotoxin-free recombinant protein can be used in cell culture, as an IL-23 ELISA Standard, and as a Western Blot Control.
None at this time

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