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Bovine CXCL9 (MIG) (Yeast-derived Recombinant Protein) - 100 micrograms

RP0025B-100
$900.00
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Bulk quantities of Bovine CXCL9 protein are available.
Please contact us for pricing.

Bovine CXCL9 Specifications

Molecular Weight (calculated) - 11.9kDa

Amino Acid Sequence - VPAIRNGRCS CINTSQGMIH PKSLKDLKQF APSPSCEKTE IIATMKNGNE ACLNPDLPEV KELIKEWEKQ VNQKKKQRKG KKYKKTKKVP KVKRSQRPSQ KKTT (104)

Gene ID - 513990

Homology Across Species
Bos taurus (cattle) CXCL9 – 100%
Bison bison bison (bison) CXCL9 – 100%
Bos indicus (zebu) CXCL9 – 100%
Bos mutus (wild yak) CXCL9 – 100%
Syncerus caffer (African buffalo) CXCL9 – 98%
More - https://blast.ncbi.nlm.nih.gov/

Endotoxin - Naturally endotoxin-free

Applications

Cell Culture, ELISA Standard, Western Blot Control

CXCL9 Background

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family. It is also commonly known as Monokine Induced by Gamma interferon (MIG). CXCL9 (MIG) is a T-cell chemoattractant, which is induced by IFN-gamma. It is closely related to two other CXC chemokines -CXCL10 and CXCL11. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL9 (MIG) elicits its effects by binding to the cell surface chemokine receptor CXCR3.

Alternate Names - CXCL9, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9

Bovine CXCL9 (MIG) (Yeast-derived Recombinant Protein) - 100 micrograms
Catalog No.:
RP0025B-100
Quantity:
100 ug
Source:
The Bovine CXCL9 (MIG) recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Bovine CXCL9 recombinant protein has a predicted molecular weight of 11.9 kDa.
Protein Sequence:
VPAIRNGRCS CINTSQGMIH PKSLKDLKQF APSPSCEKTE IIATMKNGNE ACLNPDLPEV KELIKEWEKQ VNQKKKQRKG KKYKKTKKVP KVKRSQRPSQ KKTT (104)
Alias:
MIG
Country of Origin:
USA
Applications:
The bovine CXCL9 (MIG) endotoxin-free recombinant protein can be used in cell culture, as a CXCL9/MIG ELISA Standard, and as a Western Blot Control.

31846797

Biomarkers of cell-mediated immunity to bovine tuberculosis.

Palmer MV, Thacker TC, Rabideau MM, Jones GJ, Kanipe C, Vordermeier HM, Ray Waters W.

Vet Immunol Immunopathol. 2020 Feb;220:109988. doi: 10.1016/j.vetimm.2019.109988. Epub 2019 Nov 30.

Applications: Measurement of bovine CXCL9 and CXCL10 in plasma by ELISA

Abstract

Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs), are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the current study was to evaluate a panel of cytokines and chemokines for potential use as diagnostic readouts indicative of Mycobacterium bovis (M. bovis) infection in cattle. A gene expression assay was used to determine the kinetics of the response to M. bovis purified protein derivative and a fusion protein consisting of ESAT-6, CFP10, and Rv3615c upon aerosol infection with ∼104 cfu of M. bovis. The panel of biomarkers included: IFN-γ, CXCL9, CXCL10, CCL2, CCL3, TNF-α, IL-1α, IL-1β, IL-1Ra, IL-22, IL-21 and IL-13. Protein levels of IFN-γ, CXCL9, and CXCL10 were determined by ELISA. Findings suggest that CXCL9, CXCL10, IL-21, IL-13, and several acute phase cytokines may be worth pursuing as diagnostic biomarkers of M. bovis infection in cattle.


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