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Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-gamma belongs. IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-gamma is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
Alternate Names - IFNG, IFG, IFI, interferon, gamma, interferon gamma
Homology Across Species
Macaca fascicularis (crab-eating macaque) IFNγ – 100%
Macaca mulatta (Rhesus monkey) IFNγ – 100%
Macaca nemestrina (pig-tailed macaque) IFNγ – 100%
Macaca thibetana (Tibetan macaque) IFNγ – 99%
Chlorocebus sabaeus (green monkey) IFNγ – 99%
Rhinopithecus roxellana (golden snub-nosed monkey) IFNγ – 99%
Mandrillus leucophaeus (drill) IFNγ – 99%
Theropithecus gelada (gelada) IFNγ – 99%
Piliocolobus tephrosceles (Ugandan red Colobus) IFNγ – 98%
More - https://blast.ncbi.nlm.nih.gov/
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