Bulk quantities of Bovine CTLA-4 protein are available.
Please contact us for pricing.
Molecular Weight (calculated) - 13.8kDa
Amino Acid Sequence - FSKGMNVTQP PVVLASSRGV ASFSCEYESS GKADEVRVTV LREAGSQVTE VCAGTYMVED ELTFLDDSTC IGTSRGNKVN LTIQGLRAMD TGLYVCKVEL MYPPPYYVGI GNGTQIYVID PEPCPDSD (128)
Gene ID - 281732
Homology Across Species
Bos taurus (cattle) CTLA-4 – 100%
Bison bison bison (bison) CTLA-4-100%
Bos grunniens (domestic yak) CTLA-4 – 100%
Bos indicus (zebu) CTLA-4 – 100%
Bos mutus (wild yak) CTLA-4-100%
Bubalus bubalis (water buffalo) CTLA-4 – 100%
Bubalus carabanensis (carabao) CTLA-4 – 100%
Capra hircus (goat) CTLA-4 – 96%
Pantholops hodgsonii (chiru) CTLA-4 – 96%
Ovis aries (sheep) CTLA-4 – 95%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.
Alternate Names - CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
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