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Bovine sCTLA-4 Recombinant Protein - 5 micrograms

RP1411B-005
$150.00
Data SheetAdd to Cart

Bulk quantities of proteins are available. Please contact us for bulk pricing.

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.

sCTLA-4 Homology Across Species
Bos taurus (cattle) CTLA-4 – 100%
Bison bison bison (bison) CTLA-4-100%
Bos grunniens (domestic yak) CTLA-4 – 100%
Bos indicus (zebu) CTLA-4 – 100%
Bos mutus (wild yak) CTLA-4-100%
Bubalus bubalis (water buffalo) CTLA-4 – 100%
Bubalus carabanensis (carabao) CTLA-4 – 100%
Capra hircus (goat) CTLA-4 – 96%
Pantholops hodgsonii (chiru) CTLA-4 – 96%
Ovis aries (sheep) CTLA-4 – 95%

Catalog No.:
RP1411B-005
Quantity:
5 ug
Source:
The Bovine sCTLA-4 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Bovine sCTLA-4 recombinant protein has a predicted molecular weight of 13.8 kDa.
Protein Sequence:
FSKGMNVTQP PVVLASSRGV ASFSCEYESS GKADEVRVTV LREAGSQVTE VCAGTYMVED ELTFLDDSTC IGTSRGNKVN LTIQGLRAMD TGLYVCKVEL MYPPPYYVGI GNGTQIYVID PEPCPDSD (128)
Alias:
CD152
Country of Origin:
USA
Applications:
The Bovine sCTLA-4 endotoxin-free recombinant protein can be used in cell culture, as an CTLA-4 ELISA Standard, and as a Western Blot Control.
None at this time

Ordering Information & Terms and Conditions

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Sales Order Entry
Kingfisher Biotech, Inc.
1000 Westgate Drive
Suite 123
Saint Paul, MN 55114
USA

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