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Macrophage colony-stimulating factor (M-CSF), also known as CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF enhances expression of differentiation antigens and stimulates chemotactic, phagocytic and the killing activities of monocytes. M-CSF also stimulates production of several cytokines, including GM- CSF, G-CSF and IL-6 by priming monocytes. It also stimulates production and secretion of IL-8 and reactive nitrogen intermediates. In addition to the stimulation of hematopoiesis, M-CSF also stimulates differentiation and proliferation of osteoclast progenitor cells and cytotrophoblasts.
Alternate Names - CSF1, CSF-1, MCSF, colony stimulating factor 1
Amino Acid Homology Across Species
Macaca fascicularis (crab-eating macaque) M-CSF – 100%
Cercocebus atys (sooty mangabey) M-CSF – 100%
Chlorocebus sabaeus (green monkey) M-CSF – 100%
Colobus angolensis palliates M-CSF – 100%
Macaca mulatta (Rhesus monkey) M-CSF – 100%
Papio anubis (olive baboon) M-CSF – 100%
Piliocolobus tephrosceles (Ugandan red Colobus) M-CSF – 100%
Rhinopithecus roxellana (golden snub-nosed monkey) M-CSF – 100%
Theropithecus gelada (gelada) M-CSF – 100%
More… https://blast.ncbi.nlm.nih.gov
EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSGQG HERQREGS (158)
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