Bulk quantities of Bovine IL-12 p70 protein are available.
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Molecular Weight (calculated) - 57.6kDa
Amino Acid Sequence - MWELEKNVYV VELDWYPDAP GETVVLTCDT PEEDGITWTS DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEALSRSLL LLHKKEDGIW STDILKDQKE PKAKSFLKCE AKDYSGHFTC WWLTAISTDL KFSVKSSRGS SDPRGVTCGA ALLSAEKVSL EHREYNKYTV ECQEGSACPA AEESLLIEVV VEAVHKLKYE NYTSSFFIRD IIKPDPPKNL QLRPLKNSRQ VEVSWEYPDT WSTPHSYFSL TFCVQVQGKN KREKKLFMDQ TSAKVTCHKD ANVRVQARDR YYSSFWSEWA SVSCS (305) **LINKER** RSLPTTTASP GRSCLDYSQN LLRAVSNTLQ KARQTLEFYS CTSEEIDHED ITKDKTSTVE ACLPLELATN ESCLASRETS FITNGHCLAS GKTSFMTTLC LRSIYEDLKM YHVEFQAMNA KLLMDPKRQI FLDQNMLAAI AELMQALNFD SETVPQKPSL KELDFYKTKV KLCILLHAFR IRAVTIDRMM SYLSSS (196)
Gene ID - 281856 (p35 subunit); 281857 (p70 subunit)
Homology Across Species
Bos taurus (cattle) IL-12p70 - 100%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
IL-12 is a member of the IL-12 family, which includes IL-12, IL-23, IL-27, and IL-35. Like other IL-12 family members, IL-12 is a heterodimeric cytokine. IL-12 is encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer, and a homodimer of p40 are formed following protein synthesis. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-gamma and TNF-alpha from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-gamma.
Alternate Names - IL-12A, CLMF1, NKSF1, p35; IL-12B, CLMF2, NKSF2, p40
MWELEKNVYV VELDWYPDAP GETVVLTCDT PEEDGITWTS DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEALSRSLL LLHKKEDGIW STDILKDQKE PKAKSFLKCE AKDYSGHFTC WWLTAISTDL KFSVKSSRGS SDPRGVTCGA ALLSAEKVSL EHREYNKYTV ECQEGSACPA AEESLLIEVV VEAVHKLKYE NYTSSFFIRD IIKPDPPKNL QLRPLKNSRQ VEVSWEYPDT WSTPHSYFSL TFCVQVQGKN KREKKLFMDQ TSAKVTCHKD ANVRVQARDR YYSSFWSEWA SVSCS (305) **LINKER** RSLPTTTASP GRSCLDYSQN LLRAVSNTLQ KARQTLEFYS CTSEEIDHED ITKDKTSTVE ACLPLELATN ESCLASRETS FITNGHCLAS GKTSFMTTLC LRSIYEDLKM YHVEFQAMNA KLLMDPKRQI FLDQNMLAAI AELMQALNFD SETVPQKPSL KELDFYKTKV KLCILLHAFR IRAVTIDRMM SYLSSS (196)
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