Mouse Oncostatin M (OSM) Do-It-Yourself ELISA, ≤10 Plates

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OSM (Oncostatin M) is a secreted cytokine involved in homeostasis and most chronic illnesses. OSM, a member of the IL-6 (gp130) family of proteins, inhibits the proliferation of a number of tumor cell lines and plays a significant role in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. Of all IL-6-type cytokines studied so far, OSM displays the broadest signaling profile. LIF and OSM proteins activate the JAK/STAT pathway, the MAPK protein kinases ERK1 and ERK2, the stress-activated protein kinases p38 and c-Jun N-terminal kinase (JNK), the phosphatidylinositol-3-kinase (PI3K) AKT pathway and protein kinase C delta (PRKCD). In addition, OSM exhibits many other effects by regulating the production of other cytokines including IL-6, G-CSF and GM-CSF in endothelial cells. OSM may be a tumor promoter that will provide a potential target for antiangiogenic therapy.

The Mouse OSM Do-It-Yourself ELISA contains capture antibody, protein standard, and detection antibody for development of a Mouse OSM ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Optimal buffers, concentrations, incubation times, incubation temperatures, and methods for the ELISA have not been determined. A working knowledge of ELISA is strongly recommended. The quantities of components provided are not matched. Components may also be purchased separately. 

Component Use Quantity Catalog #
Anti-Mouse OSM Polyclonal Antibody Capture Antibody 100 µg KP1436M-100
Biotinylated Anti-Mouse OSM Polyclonal Antibody Detection Antibody 50 µg KPB1437M-050
Mouse OSM Recombinant Protein Standard 5 µg RP1222M-005

Catalog No.:
1 Pack
Country of Origin:
The Mouse OSM Do-It-Yourself ELISA contains capture antibody, standard, and detection antibody for development of a Mouse OSM ELISA.
None at this time

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