The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1 alpha (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
Reactivity - ELISA
Bovine IL-1β - None
Canine IL-1β - Strong
Dolphin IL-1β - None
Equine IL-1β - None
Feline IL-1β - None
Guinea Pig IL-1β - None
Human IL-1β - None
Mouse IL-1β - None
Ovine IL-1β - None
Rabbit IL-1β - None
Swine IL-1β - None
Turkey IL-1β - None
Canine IL-1β ELISA Data
Interleukin-1β expression is increased in the duodenum of dogs with idiopathic inflammatory bowel disease.
Hawes M, Riddle A, Kirk J, Jergens A, Allenspach K.
Vet Rec. 2018 Nov 3;183(17):536. doi: 10.1136/vr.104495. Epub 2018 May 9.
Applications: Measurement of canine IL-1 beta in tissue homogenates supernatant in dogs with IBD by ELISA.
Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum.
Sawyere DM, Lanz OI, Dahlgren LA, Barry SL, Nichols AC, Werre SR.
Vet Surg. 2016 Jul;45(5):582-6. doi: 10.1111/vsu.12506.
Applications: Measurement of canine IL-1RA, IL-1 beta, and TNF alpha in serum and plasma by ELISA
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