Bulk quantities of Equine SCF antibody are available.
Please contact us for pricing.
Equine SCF ELISA Data
Reactivity - ELISA
Recombinant equine SCF - Strong
Recombinant bovine SCF - Weak
Recombinant canine SCF - None
Recombinant canine SCF - None
Recombinant chicken SCF - None
Recombinant feline SCF - Weak
Recombinant human SCF - Weak
Recombinant mouse SCF - None
Recombinant rabbit SCF - None
Recombinant swine SCF - Weak
Recombinant zebra finch SCF - None
Quantity - 100 ug
Antibody Type - Polyclonal
Host - Rabbit
Immunogen - Recombinant Equine SCF
Purification - Antigen-affinity
Label - None
SCF, often known as Kit Ligand, KITL or KITLG, is involved in pathways that control the regulation of cell survival, migration and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, and melanogenesis. SCF binding to the receptor-type protein-tyrosine kinase KIT, induces a cell signaling pathway that activates several other cell signaling pathways, including PIK3R1/AKT1, GRB2, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1, and STAT signaling events. The effects of SCF on these secondary pathways further allow it to play a role in many or the major cellular processes. The SCF, of most vertebrates, has a soluble form as well as the membrane bound type I receptor form. Mutations in the SCF pathway may result in a broad range of abnormalities including anemia, and sterility. SCF and KIT interaction has been shown to promote the growth of cancer cells and organoids in culture, and xenograft tumors in mice. SCF is being utilized in many animal model systems, from metastasis research in breast tumor-bearing arthritic mice to the genetic linkage to de-pigmentation in pigs. Interestingly, a second SCF pathway was retained in zebrafish, after a whole genome duplication, and is now undergoing divergent evolution.
Alternate Names - KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
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