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The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
Alternate Names - IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist
Homology Across Species
Canis lupus familiaris (dog) IL-1RA - 100%
Canis lupus dingo (dingo) IL-1RA - 100%
Nyctereutes procyonoides (raccoon dog) IL-1RA - 100%
Vulpes lagopus (Arctic fox) IL-1RA - 100%
Vulpes vulpes (red fox) IL-1RA - 100%
More - https://blast.ncbi.nlm.nih.gov/
Photobiomodulation (450 nm) alters the infection of periodontitis bacteria via the ROS/MAPK/mTOR signaling pathway
Li H, Sun T, Liu C, Cao Y, Liu X.
Free Radic Biol Med . 2020 May 20;152:838-853. doi: 10.1016/j.freeradbiomed.2020.01.184. Epub 2020 Jan 31.
Applications: Measurement of canine IL-1RA in saliva samples by ELISA
Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum.
Sawyere DM, Lanz OI, Dahlgren LA, Barry SL, Nichols AC, Werre SR.
Vet Surg. 2016 Jul;45(5):582-6. doi: 10.1111/vsu.12506.
Applications: Measurement of canine IL-1RA, IL-1 beta, and TNF alpha in serum and plasma by ELISA
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