Bulk quantities of Rat CXCL9 protein are available.
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Molecular Weight (calculated) - 12.0kDa
Amino Acid Sequence - TLVIRNQRCS CISTSQGTFH YKSLKDLKQF APSPNCNKTE IIATLKNGDQ TCLDPDSARV KKLMKEWEKK ISQKKKQKRG KNHQRSKKTR KAKTPHHPES KKTA (104)
Gene ID - 246759
Homology Across Species
Rattus rattus (black rat) CXCL9 – 100%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family. It is also commonly known as Monokine Induced by Gamma interferon (MIG). CXCL9 (MIG) is a T-cell chemoattractant, which is induced by IFN-gamma. It is closely related to two other CXC chemokines -CXCL10 and CXCL11. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL9 (MIG) elicits its effects by binding to the cell surface chemokine receptor CXCR3.
Alternate Names - CXCL9, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
Anti-streptococcal antibody and T-cell interactions with vascular endothelial cells initiate the development of rheumatic carditis.
Sikder S, Rush CM, Govan BL, Alim MA, Ketheesan N.
J Leukoc Biol. 2020 Feb;107(2):263-271. doi: 10.1002/JLB.4MA0919-096RR. Epub 2019 Oct 16.
Applications: T-cell migration assay
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