Bulk quantities of Canine IL-4 protein are available.
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Molecular Weight (calculated) - 12.8kDa
Amino Acid Sequence - HNFNITIKEI IKMLNILTAR NDSCMELTVK DVFTAPKNTS DKEIFCRAAT VLRQIYTHNC SNRYLRGLYR NLSSMANKTC SMNEIKKSTL KDFLERLKVI MQKKYYRH (108)
Gene ID - 403785
Homology Across Species
Canis lupus familiaris (dog) IL-4 - 100%
Vulpes lagopus (Arctic fox) IL-4 - 100%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
Interleukin-4 (IL-4) induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.
Alternate Names - IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4, interleukin 4
Elevated circulating Th2 but not group 2 innate lymphoid cell responses characterize canine atopic dermatitis.
Früh SP, Saikia M, Eule J, Mazulis CA, Miller JE, Cowulich JM, Oyesola OO, Webb LM, Peng SA, Cubitt RL, Danko CG, Miller WH, Tait Wojno ED.
Vet Immunol Immunopathol. 2020 Jan 24;221:110015. doi: 10.1016/j.vetimm.2020.110015. [Epub ahead of print]
Applications: In vitro culture of CD4+ T cells and CD25+ ILCs
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