Bulk quantities of proteins are available. Please contact us for bulk pricing.
Tumor necrosis factor ligand superfamily member 11 (TNFSF11) also known as Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF) is a member of the tumor necrosis factor ligand (TNF) ligand family. Nineteen cytokines have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. Family members include TNF beta (TNFSF1), TNF alpha (TNFSF2), Lymphotoxin beta (TNFSF3), OX40 Ligand (TNFSF4), CD40 Ligand (TNFSF5), Fas Ligand (TNFSF6), CD27 Ligand (TNFSF7), CD30 Ligand (TNFSF8), 4-1BB Ligand (TNFSF9), TRAIL (TNFSF10), TRANCE/RANKL (TNFSF11), TWEAK (TNFSF12), APRIL(TNFSF13), BAFF (TNFSF13B), LIGHT (TNFSF14), TL1A/VEGI (TNFSF15), and GITR Ligand (TNFSF18). RANKL regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.
Alternate Names - TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNLG6B, tumor necrosis factor superfamily member 11, TNF superfamily member 11
Homology Across Specie
Bos taurus (cattle) RANKL – 100%
Ovis aries (sheep) RANKL – 100%
Capra hircus (goat) RANKL – 100%
Bison bison bison (American buffalo) RANKL – 100%
Bos indicus (zebu) RANKL – 100%
Bos mutus (wild yak) RANKL – 100%
Bubalus bubalis (water buffalo) RANKL – 99%
Oryx dammah (scimitar-horned oryx) RANKL – 100%
More - https://blast.ncbi.nlm.nih.gov/
Please note that Cookies and JavaScript are required for you to view this website.
Check if you have Cookies and JavaScript enabled in your browser