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Swine C3a (Yeast-derived Recombinant Protein) - 100 micrograms

RP1132S-100
$900.00
In Stock
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Bulk quantities of proteins are available. Please contact us for bulk pricing.

C3a is an effector molecule of both the classical and alternative complement pathways for a broad range of functions including T cell activation and survival, angiogenesis stimulation, chemotaxis, mast cell degranulation, and macrophage activation. C3a produces both pro- and anti-inflammatory responses. C3a, a 77 amino acid long anaphylatoxin, is produced when C3 convertases act on the N-terminal chain of the C3 protein. The activation of the C3 protein fragments it into two proteins. The smaller protein, C3a, promotes an inflammatory reaction while the larger, called C3b, binds to the surface of many microbial cells. The binding of C3a to the specific G protein-coupled receptor, C3aR, has been shown to be involved in several diseases such as rheumatoid arthritis, septic shock syndrome, age-related macular degeneration, and asthma. The immune response, initiated by C3a, acts by stimulating mast cell degranulation. Inhibiting the binding of C3a to C3aR with antagonists, such as diiminoisoindolines, diminishes the inflammatory response by disrupting the cascade. In many cases, it has been shown to be strong enough to counteract the pro-inflammatory effects of C5a.
Swine C3a (Yeast-derived Recombinant Protein) - 100 micrograms
Catalog No.:
RP1132S-100
Quantity:
100 ug
Source:
The Swine C3a recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Swine C3a recombinant protein has a predicted molecular weight of 9.1 kDa.
Protein Sequence:
SVQLMEKRMD KLGQYSKDVR RCCEHGMRDN PMKFSCQRRA QFIQHGDACV KAFLDCCEYI AKLRQQHSRN KPLGLAR (77)
Alias:
Complement Component 3a
Country of Origin:
USA
Applications:
The Swine C3a endotoxin-free recombinant protein can be used in cell culture, as an C3a ELISA Standard, and as a Western Blot Control.
None at this time

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