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CartCynomolgus Monkey CXCL10 (IP-10) (Yeast-derived Recombinant Protein) - 25 micrograms
Bulk quantities of proteins are available. Please contact us for bulk pricing.
C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is a member of the C-X-C chemokine family. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3.
Alternate Names - CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
Homology Across Species
Macaca fascicularis (crab-eating macaque) CXCL10 – 100%
Macaca mulatta (Rhesus monkey) CXCL10 – 100%
Papio anubis (olive baboon) CXCL10 – 100%
Rhinopithecus roxellana (golden snub-nosed monkey) CXCL10 – 100%
Mandrillus leucophaeus (drill) CXCL10 – 100%
Cercocebus atys (sooty mangabey) CXCL10 – 100%
Rhinopithecus bieti (black snub-nosed monkey) CXCL10 – 100%
Theropithecus gelada (gelada) CXCL10 – 100%
Trachypithecus francoisi (Francois's langur) CXCL10 – 100%
​More - https://blast.ncbi.nlm.nih.gov
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