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CartCynomolgus Monkey CCL19 (MIP-3 beta) (Yeast-derived Recombinant Protein) - 25 micrograms
Pricing on bulk quantities of proteins is available. Please email your request.
CCL19 (also known as MIP-3 beta) and CCL21, the ligands for CCR7, are involved in controlling a diverse array of migratory events in adaptive immune functions such as the homing of Dendritic and T-Cells to areas of lymphoid tissues where T-cell priming occurs. These predominant chemokines play an important role in many aspects of the immune model systems, as well as general animal health. CCL19 or CCL21 induced expression in tumor tissue, from various cancer models, results in an inhibition of tumor growth and may even lead to a complete rejection of several tumors due to this increased infiltration by dendritic and/or T-cells. Both CCL19 and CCL21 are predominantly expressed in the thymic medulla and also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T-cell function, and lymphocyte migration from tissues. CCL19, unlike CCL21, induces beta arrestin recruitment, which leads to receptor desensitization and internalization. Effective priming of T-cell responses depends on the interactions between naive T-cells and antigen-presenting cells (APCs). Several animal model systems have been used to characterize the role of the CCL19, CCL21, CCR7 ligand system in T-cell responses during infection.
Alternate Names - CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine ligand 19
Amino Acid Homology
Cercocebus atys (sooty mangabey) CCL19 – 100%
Chlorocebus sabaeus (green monkey) CCL19 – 100%
Colobus angolensis palliates (Peter’s Angolan Colobus) CCL19 – 100%
Macaca fascicularis (Cynomolgus monkey) CCL19 – 100%
Macaca mulatta (Rhesus monkey) CCL19 – 100%
Macaca nemestrina (pig-tailed macaque) CCL19 – 100%
Mandrillus leucophaeus (drill) CCL19 – 100%
Papio anubis (olive baboon) CCL19 – 100%
Rhinopithecus bieti (black snub-nosed monkey) CCL19 – 99%
Rhinopithecus roxellana (golden snub-nosed monkey) CCL19 – 99%
Pongo abelii (Sumatran orangutan) CCL19 – 97%
Gorilla gorilla gorilla (western lowland gorilla) CCL19 – 96%
Homo sapiens (human) CCL19 – 96%
Pan paniscus (pygmy chimpanzee) CCL19 – 95%
Pan troglodytes (chimpanzee) CCL19 – 95%
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USA
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