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IL-18 is a member of the IL-1 superfamily. The interleukin-1 superfamily has 11 members, which have similar gene structure. Interleukin 18 (IL-18), also know an IL-1F4, was isolated as a co-factor that, in synergism with IL-12, stimulated the production of IFN gamma in Th1 cells. It is now understood that IL-18 is an important link between innate and adaptive immune responses and a regulator of both cellular and humoral immunity. IL-18 is secreted in its active form following cleavage by caspase 1 in response to inflammatory and infectious stimuli. In addition to its effects on Th1 cells, IL-18 is a strong stimulator of the activity of natural killer cells alone or in combination with IL-15, and of CD8+ lymphocytes. Together with IL-2, IL-18 can also stimulate the production of IL-13 and of other Th2 cytokines. IL-18 plays a role in numerous inflammatory-associated disorders.
Alternate Names - IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18
IL-18 Homology Across Species
Homo sapiens (human) IL-18 – 100%
Pan paniscus (pygmy chimpanzee) IL-18 – 100%
Pan troglodytes (chimpanzee) IL-18 – 100%
Gorilla gorilla gorilla (western lowland gorilla) IL-18 – 99%
Pongo abelii (Sumatran orangutan) IL-18 – 98%
Chlorocebus sabaeus (green monkey) IL-18 – 96%
Colobus angolensis palliates (Peter’s Angolan Colobus) IL-18 – 96%
Macaca fascicularis (Cynomolgus monkey) IL-18 – 96%
Macaca mulatta (Rhesus monkey) IL-18 – 96%
Macaca nemestrina (pig-tailed macaque) IL-18 – 96%
Rhinopithecus bieti (black snub-nosed monkey) IL-18 – 96%
Rhinopithecus roxellana (golden snub-nosed monkey) IL-18 – 96%
More - https://blast.ncbi.nlm.nih.gov/
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