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Chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemotactic protein-1 (MCP-1), is a small cytokine belonging to the CC chemokine family. There are at least 27 distinct members of the C-C subgroup reported for mammals. They are characterized by two adjacent cysteines. CCL2 (MCP-1) recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. CCL2 (MCP-1) is implicated in pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis.
Alternate Names - CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
Homology Across Species
Homo sapiens (human) CCL2 – 100%
Pan troglodytes (chimpanzee) CCL2 – 100%
Gorilla gorilla gorilla (western lowland gorilla) CCL2 – 100%
Nomascus leucogenys (northern white-cheeked gibbon) CCL2 – 100%
Colobus angolensis palliates (Peter’s Angolan Colobus) CCL2 – 99%
Macaca fascicularis (Cynomolgus monkey) CCL2 – 99%
Macaca mulatta (Rhesus monkey) CCL2 – 99%
Macaca nemestrina (pig-tailed macaque) CCL2 – 99%
Pan paniscus (pygmy chimpanzee) CCL2 – 99%
Papio anubis (olive baboon) CCL2 – 99%
Piliocolobus tephrosceles (Ugandan red Colobus) CCL2 – 99%
Pongo abelii (Sumatran orangutan) CCL2 – 99%
More… https://blast.ncbi.nlm.nih.gov
QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT (76)
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