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CartZebra Finch SCF (Stem Cell Factor) (Yeast-derived Recombinant Protein) - 5 micrograms
Bulk quantities of proteins are available. Please contact us for bulk pricing.
SCF, often known as Kit Ligand, KITL or KITLG, is involved in pathways that control the regulation of cell survival, migration and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, and melanogenesis. SCF binding to the receptor-type protein-tyrosine kinase KIT, induces a cell signaling pathway that activates several other cell signaling pathways, including PIK3R1/AKT1, GRB2, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1, and STAT signaling events. The effects of SCF on these secondary pathways further allow it to play a role in many or the major cellular processes. The SCF, of most vertebrates, has a soluble form as well as the membrane bound type I receptor form. Mutations in the SCF pathway may result in a broad range of abnormalities including anemia, and sterility. SCF and KIT interaction has been shown to promote the growth of cancer cells and organoids in culture, and xenograft tumors in mice. SCF is being utilized in many animal model systems, from metastasis research in breast tumor-bearing arthritic mice to the genetic linkage to de-pigmentation in pigs. Interestingly, a second SCF pathway was retained in zebrafish, after a whole genome duplication, and is now undergoing divergent evolution.
Homology Across Species
Taeniopygia guttata (zebra finch) SCF – 100%
Sturnus vulgaris (common starling) SCF – 99%
Lonchura striata domestica (Bengalese finch) SCF – 98%
Geospiza fortis (medium ground-finch) SCF – 98%
Serinus canaria (common canary) SCF – 98%
QSSCGNPVTD DVNDIAKLVG NLPNDYMITL KYVPKMDSLP SHCWLHLMVP EFSRSLHNLL QKFSDIPDMS DVLSNYSIIN NLTRIINDLM ACLAFDKNKD FVKENGHLYE EGHFIPEDFF RHFNSTIEVY KESADRLDKN DCILPSTVGT PENDSRVAVT KTFLFPPVAA SSLRNDSIGS STSSNKEALG FISSSSLQGI SIALTSLLSL LIGFILGAIY WKKIHPKSRP ESDETTQCRD YQEENEIRYI VSLKIYLHYD IGKDLMQVAE RLGL (274)
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Kingfisher Biotech, Inc.
1000 Westgate Drive
Suite 123
Saint Paul, MN 55114
USA
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Kingfisher Biotech brand products are warranted by Kingfisher Biotech, Inc. to meet stated product specifications and to conform to label descriptions when used, handled and stored according to instructions. Unless otherwise stated, this warranty is limited to one year from date of sale. Kingfisher Biotech’s sole liability for the product is limited to replacement of the product or refund of the purchase price. Kingfisher Biotech brand products are supplied for research applications. They are not intended for medicinal, diagnostic or therapeutic use. The products may not be resold, modified for resale or used to manufacture commercial products without prior written approval from Kingfisher Biotech.
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Returns
Please call customer service before returning any products for refund, credit or replacement. NO returns will be accepted without prior written authorization. Returns are subject to a restocking fee of 20%.