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CartHuman IL-33 (Yeast-derived Recombinant Protein) - 100 micrograms
Bulk quantities of proteins are available. Please contact us for bulk pricing.
IL-33 (Interleukin 33) is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). It is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells. This cytokine was previously named NF-HEV nuclear factor (NF) in high endothelial venules' (HEVs) since it was originally identified in these specialized cells.[9] IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine. As a cytokine, IL-33 interacts with the receptors ST2 (also known as IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.
Alternate Names - IL33, C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, Interleukin 33, IL-33
Homology Across Species
Homo sapiens (human) IL-33 – 100%
Pan troglodytes (chimpanzee) IL-33 – 100%
Gorilla gorilla gorilla (western lowland gorilla) IL-33 – 99%
Pan paniscus (pygmy chimpanzee) IL-33 – 99%
Pongo abelii (Sumatran orangutan) IL-33 – 95%
More… https://blast.ncbi.nlm.nih.gov
SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET (159)
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