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CartHuman IL-1 alpha (IL-1F1) (Yeast-derived Recombinant Protein) - 5 micrograms
The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
Alternate Names - IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha
Amino Acid Homology Across Species
Homo sapiens (human) IL-1α – 100%
Pan paniscus (pygmy chimpanzee) IL-1α – 100%
Pan troglodytes (chimpanzee) IL-1α – 100%
Gorilla gorilla gorilla (western lowland gorilla) IL-1α – 99%
Nomascus leucogenys (northern white-cheeked gibbon) IL-1α – 98%
Pongo abelii (Sumatran orangutan) IL-1α – 99%
More - https://blast.ncbi.nlm.nih.gov/
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQ (158)
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