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CartDuck CCL19 (MIP-3 beta)(Yeast-derived Recombinant Protein) - 5 micrograms
Bulk quantities of proteins are available. Please contact us for bulk pricing.
CCL19 (also known as MIP-3 beta) and CCL21, the ligands for CCR7, are involved in controlling a diverse array of migratory events in adaptive immune functions such as the homing of Dendritic and T-Cells to areas of lymphoid tissues where T-cell priming occurs. These predominant chemokines play an important role in many aspects of the immune model systems, as well as general animal health. CCL19 or CCL21 induced expression in tumor tissue, from various cancer models, results in an inhibition of tumor growth and may even lead to a complete rejection of several tumors due to this increased infiltration by dendritic and/or T-cells. Both CCL19 and CCL21 are predominantly expressed in the thymic medulla and also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T-cell function, and lymphocyte migration from tissues. CCL19, unlike CCL21, induces beta arrestin recruitment, which leads to receptor desensitization and internalization. Effective priming of T-cell responses depends on the interactions between naive T-cells and antigen-presenting cells (APCs). Several animal model systems have been used to characterize the role of the CCL19, CCL21, CCR7 ligand system in T-cell responses during infection.
Alternate Names - CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine ligand 19
Homology Across Species
Anas platyrhynchos (mallard) CCL19 – 100%
Aythya fuligula (tufted duck) CCL19 – 97%
Cygnus atratus (black swan) CCL19 – 96%
Oxyura jamaicensis (ruddy duck) CCL19 – 96%
​More - https://blast.ncbi.nlm.nih.gov/
GNNVLDCCLR TSENPIPRRI VQRYQIQLVQ DGCEIPANVF ITVRGKRLCA PLEAPWAVRL REKLDSGSAR KVPNKGN (77)
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Kingfisher Biotech, Inc.
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Kingfisher Biotech brand products are warranted by Kingfisher Biotech, Inc. to meet stated product specifications and to conform to label descriptions when used, handled and stored according to instructions. Unless otherwise stated, this warranty is limited to one year from date of sale. Kingfisher Biotech’s sole liability for the product is limited to replacement of the product or refund of the purchase price. Kingfisher Biotech brand products are supplied for research applications. They are not intended for medicinal, diagnostic or therapeutic use. The products may not be resold, modified for resale or used to manufacture commercial products without prior written approval from Kingfisher Biotech.
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