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CartHuman IL-36 alpha (Yeast-derived Recombinant Protein) - 100 micrograms
Bulk quantities of proteins are available. Please contact us for bulk pricing.
Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. There are four members of the IL-36 family which bind to the IL-36 receptor (IL1RL2/IL-1Rrp2/IL-36 receptor dimer) with varying affinities. IL36A, IL36B, and IL36G are IL-36 receptor agonists. IL36RA is an IL-36 receptor antagonist, inhibiting IL-36R signaling. The agonists are known to activate NF-κB and mitogen-activated protein kinases to induce various proinflammatory mediators. Binding of the IL-36R agonists to IL-1Rp2 recruits IL-1RAcP, activating the signaling pathway. IL-36Ra binds to IL-36R, preventing the recruitment of IL-1RAcP. IL-36 has been found to activate T cell proliferation and release of IL-2. Due to their predominant expression in epithelial tissues, IL-36 cytokines are believed to play a significant role in the pathogenesis of skin diseases, especially that of psoriasis. IL-36 has also been linked to psoriatic arthritis, systemic lupus erythematosus, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and Sjögren's syndrome. IL-36 is expressed by many cells types, most predominately keratinocytes, respiratory epithelium, various nervous tissue, and monocytes.
Alternate Names - IL-36 alpha, IL-36A, FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
Homology Across Species
Homo sapiens (human) IL-36α – 100%
Pan paniscus (pygmy chimpanzee) IL-36α – 99%
Pan troglodytes (chimpanzee) IL-36α – 99%
Pongo abelii (Sumatran orangutan) IL-36α – 98%
Gorilla gorilla gorilla (western lowland gorilla) IL-36α – 97%
More - https://blast.ncbi.nlm.nih.gov/
KIDTPQQGSI QDINHRVWVL QDQTLIAVPR KDRMSPVTIA LISCRHVETL EKDRGNPIYL GLNGLNLCLM CAKVGDQPTL QLKEKDIMDL YNQPEPVKSF LFYHSQSGRN STFESVAFPG WFIAVSSEGG CPLILTQELG KANTTDFGLT MLF (153)
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Kingfisher Biotech, Inc.
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