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CartBovine IL-36 alpha (Yeast-derived Recombinant Protein) - 25 micrograms
Bulk quantities of proteins are available. Please contact us for bulk pricing.
Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. There are four members of the IL-36 family which bind to the IL-36 receptor (IL1RL2/IL-1Rrp2/IL-36 receptor dimer) with varying affinities. IL36A, IL36B, and IL36G are IL-36 receptor agonists. IL36RA is an IL-36 receptor antagonist, inhibiting IL-36R signaling. The agonists are known to activate NF-κB and mitogen-activated protein kinases to induce various proinflammatory mediators. Binding of the IL-36R agonists to IL-1Rp2 recruits IL-1RAcP, activating the signaling pathway. IL-36Ra binds to IL-36R, preventing the recruitment of IL-1RAcP. IL-36 has been found to activate T cell proliferation and release of IL-2. Due to their predominant expression in epithelial tissues, IL-36 cytokines are believed to play a significant role in the pathogenesis of skin diseases, especially that of psoriasis. IL-36 has also been linked to psoriatic arthritis, systemic lupus erythematosus, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and Sjögren's syndrome. IL-36 is expressed by many cells types, most predominately keratinocytes, respiratory epithelium, various nervous tissue, and monocytes.
Alternate Names - IL-36 alpha, IL-36A, FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
Homology Across Species
Oryctolagus cuniculus (rabbit) IL-36α- 100%
More - https://blast.ncbi.nlm.nih.gov/
NIQDINHLVW VLQGQALTAV PRKDQMDPVT VTLVSCKYTE TLEKGRGNPV YLGLKEPELC LFCTKVKGQP TLQLQERNIM DLYHQTEPVK PFLFYHDQNG RASSFESVAF PGWFIGSCSC GGCPVIITQE LGKIYTTDFG FTVLQP (146)
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Kingfisher Biotech, Inc.
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Kingfisher Biotech brand products are warranted by Kingfisher Biotech, Inc. to meet stated product specifications and to conform to label descriptions when used, handled and stored according to instructions. Unless otherwise stated, this warranty is limited to one year from date of sale. Kingfisher Biotech’s sole liability for the product is limited to replacement of the product or refund of the purchase price. Kingfisher Biotech brand products are supplied for research applications. They are not intended for medicinal, diagnostic or therapeutic use. The products may not be resold, modified for resale or used to manufacture commercial products without prior written approval from Kingfisher Biotech.
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