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CartCanine IL-36 Receptor Antagonist (IL-1F5) (Yeast-derived Recombinant Protein) - 5 micrograms
Bulk quantities of Canine IL-3RA protein are available.
Please contact us for pricing.
Canine IL-36RA Specifications
Molecular Weight (calculated) - 16.9kDa
Amino Acid Sequence - VLSGALCFRM KDAALKVLYL HDNQLLAGGL HAGKVIKGEE ISVVPNRSLD AKLSPVILGV QGGSQCLSCG TGQEPTLKLE PVNIMELYLG AKESKSFTFY RRDTGLTSSF ESAAYPGWFL CTVPEADQPL RLTQLSEDAS WDNPITDFYF QQCD (154)
Gene ID - 611869
Homology Across Species
Canis lupus familiaris (dog) IL-36RA – 100%
Canis lupus dingo (dingo) IL-36RA – 100%
Vulpes lagopus (Arctic fox) IL-36RA – 100%
Nyctereutes procyonoides (raccoon dog) IL-36RA – 99%
Vulpes vulpes (red fox) IL-36RA – 99%
Leptonychotes weddellii (Weddell seal) IL-36RA – 99%
Mirounga leonina (Southern elephant seal) IL-36RA – 99%
Mirounga angustirostris (Northern elephant seal) IL-36RA – 99%
Phoca vitulina (harbor seal) IL-36RA – 98%
Halichoerus grypus (gray seal) IL-36RA – 98%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Applications
Cell Culture, ELISA Standard, Western Blot Control
IL-36RA Background
The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
Alternate Names - IL36RN, FIL1, FIL1(DELTA), FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, IL-36Ra, PSORS14, interleukin 36 receptor antagonist
VLSGALCFRM KDAALKVLYL HDNQLLAGGL HAGKVIKGEE ISVVPNRSLD AKLSPVILGV QGGSQCLSCG TGQEPTLKLE PVNIMELYLG AKESKSFTFY RRDTGLTSSF ESAAYPGWFL CTVPEADQPL RLTQLSEDAS WDNPITDFYF QQCD (154)
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Kingfisher Biotech, Inc.
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Saint Paul, MN 55114
USA
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