Bulk quantities of Human IL-36γ protein are available.
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Molecular Weight (calculated) - 17.0kDa
Amino Acid Sequence - SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND (152)
Gene ID - 56300
Homology Across Species
Homo sapiens (human) IL-36γ – 100%
Gorilla gorilla gorilla (western lowland gorilla) IL-36γ – 99%
Pan troglodytes (chimpanzee) IL-36γ – 99%
Hylobates moloch (silvery gibbon) IL-36γ – 97%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
IL-36γ is a member of the interleukin-1 cytokine family. The activity of IL-36γ is mediated via the interleukin-1 receptor-like 2 (IL1RL2/IL1R-rp2/IL-36 receptor), and is specifically inhibited by interleukin-36 receptor antagonist, (IL-36RA). Interferon-gamma, tumor necrosis factor-alpha and IL-1 β are reported to stimulate the expression of this cytokine in keratinocytes. The expression of IL-36γ in keratinocytes can also be induced by a multiple Pathogen-Associated Molecular Patterns (PAMPs). Both IL-36γ mRNA and protein have been linked to psoriasis lesions and has been used as a biomarker for differentiating between eczema and psoriasis. As with many other interleukin-1 family cytokines IL-36γ requires proteolytic cleavage of its N-terminus for full biological activity. However, unlike IL-1β the activation of IL-36γ is inflammasome-independent. IL-36γ is specifically cleaved by the endogenous protease cathepsin S as well exogenous proteases derived from fungal and bacterial pathogens.
Alternate Names - IL36G, interleukin 36, gamma, IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1H1, IL1RP2, IL1F9, interleukin 36 gamma
SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI
ND (152)
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