Bulk quantities of Mink IL-1α protein are available.
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Molecular Weight (calculated) - 18.1kDa
Amino Acid Sequence - SAAYNFRSNE KYNYMRIIKS QFILNDNLNQ SIIQQTGGNY LMAAALQNLD DAVKFDMGAY TSEDSKYPVT LRISKTRLFV SAQNEGEPVL LKEMPETPKT IKDETNLLFF WERHGTKNYF TSVAQPKLFI ATQERKLVHM ARGQPSITDF QILETQT (157)
Gene ID - 122915761
Homology Across Species
Neogale vison (American mink) IL-1α – 100%
Meles meles (Eurasian badger) IL-1α – 99%
Gulo gulo luscus (American wolverine) IL-1α – 99%
Lutra lutra (Eurasian river otter) IL-1α – 99%
Lontra canadensis (Northern American river otter) IL-1α – 99%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
Alternate Names - IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α
SAAYNFRSNE KYNYMRIIKS QFILNDNLNQ SIIQQTGGNY LMAAALQNLD DAVKFDMGAY TSEDSKYPVT LRISKTRLFV SAQNEGEPVL LKEMPETPKT IKDETNLLFF WERHGTKNYF TSVAQPKLFI ATQERKLVHM ARGQPSITDF QILETQT (157)
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