Bulk quantities of Canine CTLA-4 protein are available.
Please contact us for pricing.
Molecular Weight (calculated) - 13.4kDa
Amino Acid Sequence - KGMHVAQPAV VLASSRGVAS FVCEYGSSGN AAEVRVTVLR QAGSQMTEVC AATYTVEDEL AFLDDSTCTG TSSGNKVNLT IQGLRAMDTG LYICKVELMY PPPYYVGMGN GTQIYVIDPE PCPDSD (126)
Gene ID - 403696
Homology Across Species
Canis lupus familiaris (dog) CTLA-4 – 100%
Canis lupus dingo (dingo) CCL17 – 100%
Vulpes lagopus (Arctic fox) CCL17 – 100%
Vulpes vulpes (red fox) CCL17 – 100%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.
Alternate Names - CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
KGMHVAQPAV VLASSRGVAS FVCEYGSSGN AAEVRVTVLR QAGSQMTEVC AATYTVEDEL AFLDDSTCTG TSSGNKVNLT IQGLRAMDTG LYICKVELMY PPPYYVGMGN GTQIYVIDPE PCPDSD (126)
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