Bulk quantities of Swine IL-12 p70 protein are available.
Please contact us for pricing.
Molecular Weight (calculated) - 56.5kDa
Amino Acid Sequence - IWELEKNVYV VELDWYPNAP GEMVVLTCNT PEEDGITWTS DQSSEVLGTG KTLTIHVKEF GDAGQYTCRK GGAVLSQSLL LLHKKEDGIW STDILKDQKE PKNKSFLKCE AKNYSGRFTC WWLTAISTDL KFSVKSSRGS TDPRGVTCGT ATLSEDLGEY KKYRVECQEG SACPAAEESL PIEVVLEAVH KLKYENYTSS FFIRDIIKPD PPKNLQLNPL KNSRHVEISW EYPDTWSTPH SYFSLMFGVQ VQGKNKREKK DKLFTDQISA KVTCHKDANI RVQARDRYYS SSWSEWASVS CN (302) LINKER RSLPATTAGP GMFKCLNHSQ NLLKAVSNTL QKAKQTLEFY SCTSEEIDHE DITKDKTSTV EACLPLELAT NESCLAARET SLITNGNCLT SGKTSFMTTL CLSSIYEDLK MYHVEFQAMN AKLLMDPKRQ IFLDQNMLTA ITELMQALNF NSETVPQKPS LEELDFYKTK IKLCILLHAF RIRAVTIDRM MSYLNSS (197)
Gene ID - 397053 (p35 subunit); 397076 (p70 subunit)
Homology Across Species
Sus scrofa (pig) IL-12p70 - 100%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
IL-12 is a member of the IL-12 family, which includes IL-12, IL-23, IL-27, and IL-35. Like other IL-12 family members, IL-12 is a heterodimeric cytokine. IL-12 is encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer, and a homodimer of p40 are formed following protein synthesis. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-gamma and TNF-alpha from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-gamma.
Alternate Names - IL-12A, CLMF1, NKSF1, p35; IL-12B, CLMF2, NKSF2, p40
IWELEKNVYV VELDWYPNAP GEMVVLTCNT PEEDGITWTS DQSSEVLGTG KTLTIHVKEF GDAGQYTCRK GGAVLSQSLL LLHKKEDGIW STDILKDQKE PKNKSFLKCE AKNYSGRFTC WWLTAISTDL KFSVKSSRGS TDPRGVTCGT ATLSEDLGEY KKYRVECQEG SACPAAEESL PIEVVLEAVH KLKYENYTSS FFIRDIIKPD PPKNLQLNPL KNSRHVEISW EYPDTWSTPH SYFSLMFGVQ VQGKNKREKK DKLFTDQISA KVTCHKDANI RVQARDRYYS SSWSEWASVS CN (302) LINKER RSLPATTAGP GMFKCLNHSQ NLLKAVSNTL QKAKQTLEFY SCTSEEIDHE DITKDKTSTV EACLPLELAT NESCLAARET SLITNGNCLT SGKTSFMTTL CLSSIYEDLK MYHVEFQAMN AKLLMDPKRQ IFLDQNMLTA ITELMQALNF NSETVPQKPS LEELDFYKTK IKLCILLHAF RIRAVTIDRM MSYLNSS (197)
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