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CartCanine IL-33 (Yeast-derived Recombinant Protein) - 100 micrograms
Bulk quantities of Canine IL-33 protein are available.
Please contact us for pricing.
Canine IL-33 Specifications
Molecular Weight (calculated) - 17.6kDa
Amino Acid Sequence - SIQEYSASLS TYNDQSITFV FEDGSYEIYV EDLRKGQEKD KVLFRYYDSQ SPSHETGDDV DGQTLLVNLS PTKDKDFLLH ANNEEHSVEL QKCENQLPDQ AFFLLHRKSS ECVSFECKNN PGVFIGVKDN HLALIKVGDQ TKDSYIEKTI FKLS (154)
Homology Across Species
Canis lupus familiaris (dog) IL-33 -100%
Canis lupus dingo (dingo) IL-33 – 100%
This amino acid sequence has greater than or equal to 97% homology across various species, including, canine, racoon dog, dingo, and fox.
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Applications
Cell Culture, ELISA Standard, Western Blot Control
IL-33 Background
IL-33 (Interleukin 33) is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). It is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells. This cytokine was previously named NF-HEV nuclear factor (NF) in high endothelial venules' (HEVs) since it was originally identified in these specialized cells.[9] IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine. As a cytokine, IL-33 interacts with the receptors ST2 (also known as IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.
Alternate Names - IL33, C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, Interleukin 33, IL-33
SIQEYSASLS TYNDQSITFV FEDGSYEIYV EDLRKGQEKD KVLFRYYDSQ SPSHETGDDV DGQTLLVNLS PTKDKDFLLH ANNEEHSVEL QKCENQLPDQ AFFLLHRKSS ECVSFECKNN PGVFIGVKDN HLALIKVGDQ TKDSYIEKTI FKLS (154)
Ordering Information & Terms and Conditions
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Via Phone
Please call us at 651-646-0089 between the hours of 8:30 a.m. and 5:30 p.m. CST Mon - Fri.
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Orders can be faxed to us 24 hours a day at 651-646-0095.
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Please e-mail orders to orders@KingfisherBiotech.com.
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Please mail your order to:
Sales Order Entry
Kingfisher Biotech, Inc.
1000 Westgate Drive
Suite 123
Saint Paul, MN 55114
USA
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Kingfisher Biotech brand products are warranted by Kingfisher Biotech, Inc. to meet stated product specifications and to conform to label descriptions when used, handled and stored according to instructions. Unless otherwise stated, this warranty is limited to one year from date of sale. Kingfisher Biotech’s sole liability for the product is limited to replacement of the product or refund of the purchase price. Kingfisher Biotech brand products are supplied for research applications. They are not intended for medicinal, diagnostic or therapeutic use. The products may not be resold, modified for resale or used to manufacture commercial products without prior written approval from Kingfisher Biotech.
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Returns
Please call customer service before returning any products for refund, credit or replacement. NO returns will be accepted without prior written authorization. Returns are subject to a restocking fee of 20%.