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Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-gamma belongs. IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-gamma is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
Recombinant Chicken IFN gamma Catalog Number RP0115C contains a single amino acid substitution compared to NCBI reference sequence NP_990480.1 (Thr at position 93 in place of Ile). This amino acid substitution was corrected to match the published sequence. The corrected recombinant protein is available (Catalog Number RP0929C-005/RP0929C-025/RP0929C-100) (Ile present at position 93).
IFNγ Homology Across Species
Gallus gallus (chicken) IFNg – 99% (see above)
Meleagris gallopavo (turkey) IFNγ – 98%
Lagopus lagopus scotica(red grouse) IFNγ – 96%
More - https://blast.ncbi.nlm.nih.gov/
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